Research

Mechanisms of axonal mRNA transport

We are interested in deciphering which mechanisms contribute to the tethering of mRNA to the mitochondria, which has been shown to be a translational hub. Additionally, we are exploring what cellular conditions/ stressors influence mRNA transport on the mitochondria to better understand how local translation directly impacts neuronal survival in disease-related conditions. 

Neuronal subtype specific mitochondrial properties in selective vulnerability

 We will explore how cell specific differences in mRNA transport and mitochondrial homeostasis contributes to the mechanisms behind selective neuronal vulnerability in respect to aging. Focus on understanding how different neuronal subtypes have distinct mitochondrial needs, dynamics and response to stress will provide crucial insights into the factors that introduce vulnerability in neurodegenerative diseases.

Key Questions

How do mRNA transport and local translation mechanisms differ among various neuronal subtypes?

What is distinct about the axonal transcriptome/proteome in neurons with increased vulnerability?

Does aging have a direct impact on transport mechanisms?

Local translation in neuronal growth and regeneration

A key perspective that we are investigating is the role of local protein synthesis during initial growth and regeneration periods. We are exploring how delivery of nuclear-encoded mRNA via axonal mitochondria influences regenerative capacity following axonal injury. Additionally, we are interested in how these mechanisms contribute to the progression of neurodegenerative diseases and mitochondrial stress models.  

Key Questions

How is mRNA transport and local translation in axons altered by injury?

Do in vivo models of neurodegenerative diseases display impaired mRNA tethering to the mitochondria?