Gibbs Lab

We explore the intricate mechanisms that sustain neuronal health, with a special focus on mitochondrial function and the critical process of mRNA transport in neurons. Our research aims to understand how neurons maintain mitochondrial integrity and function, particularly in distant regions of the neuron. This involves the transport of mitochondria, local protein synthesis, and the degradation of damaged components to preserve cell health.

We are also interested in how failures in these processes can lead to neurodegenerative diseases such as Parkinson’s disease. By uncovering how neurons manage to support distal mitochondrial function and repair, we aim to understand how mitochondrial quality control pathways influence neuroprotective and regenerative mechanisms. 

Through our research, we strive to provide deeper insights into how mitochondrial homeostasis influences neuronal resilience, aging, and recovery, ultimately deepening our knowledge into the interconnection of mitochondria with neural survival pathways.